Sequin is a free, stand-alone software tool for submitting and updating entries to the EMBL, GenBank or DDBJ sequence databases.
Sequin is capable of handling simple submissions that contain a single short mRNA sequence, and complex submissions containing long sequences, multiple annotations, segmented sets of DNA, or phylogenetic and population studies.
Sequin automatically performs a number of functions that must be carried out manually in other sequence submissions programs such as BankIt.
For example, Sequin obtains the proper genetic code from the name of the organism and automatically determines coding region intervals on the nucleotide sequence by back-translation of the protein sequence.
Researchers who submit large numbers of related sequences can make use of the fact that Sequin can also interpret the name of the organism, strain, and other biological source information directly from a line of data entered along with each nucleotide sequence.
Sequin also allows the designation of groups of sequences as population, phylogentic, mutant, or environmental sets for display in the PopSet division of Entrez.
A number of powerful sequence annotation tools have been integrated into Sequin. The ORF Finder identifies open reading frames within the sequence. The Sequence Editor allows basic editing and translation of nucleotide sequences.
With the Update Sequence function, Sequin can import and align a replacement or overlapping sequence to the sequence in the record and propagate features between the two aligned sequences.
In Network-Aware mode, Sequin integrates the CDD Blast function and PubMed searching. Sequin also allows the propagation of features from one sequence in an aligned set to other sequences within the set.
